These undergraduate fellows, working under the supervision of senior HD scientists, are able to take on unique and crucial research projects that aid in the understanding of HD. They also are able to learn more about Huntington’s disease and the families that are affected, and take interest in the field of HD research early on in their career!
The 2023 Fellowship recipients are:
Samuel Moldenhauer (University of Central Florida) will, under the mentorship of Amber Southwell, PhD, use AI to automate tracing of brain regions and brain volume analysis, which could support faster preclinical development of novel therapies for HD.
Adam Monek (University of Pittsburgh) will work in the lab of Diane Carlisle, PhD, to evaluate the neuroprotective effects of metformin and its role in metabolic regulation in a mouse model of HD.
Sophie Laye (Washington University in St. Louis) will explore the molecular basis underlying neurodegeneration in HD in the lab of Hiroko Yano, PhD, by studying protein interactions with DNMT3A, a protein that plays a key role in DNA transcription.
Kaden Adams (Central Michigan University) will, under the mentorship of Gary Dunbar, PhD, study whether OligoGM1, the isolated bioactive component of a known neuroprotective compound, GM1, will have positive effects like its parent molecule in a model of HD.
At University of California, San Francisco HD Clinic, other key members of the team include a patient care coordinator (Alyson Marcelo) who helps with scheduling, insurance, and connecting patients with clinical team members; two neuropsychologists, Melanie Stephens and Kate Possin, who evaluate HD patients with cognitive symptoms and critically inform the recommendations for work accommodations, disability, or additional help at home; and two research coordinators, Chelsea Chen and Zach Lamson, who provide information to patients and families about HD research opportunities at UCSF and other nearby HD centers.
My blog this week is focused on the second Huntington’s disease (HD) clinic in the San Francisco Bay Area. Stanford has a multidisciplinary team to help HD families have the highest quality to their life when HD threatens their family. The team consists of: expert neurologists, psychiatrists, social workers, physical therapists, counselors, genetic counselors, speech pathologists and occupational therapists.
Dr. Sharon Sha-Stanford COE Director
Dr. Sharon Sha is a Clinical Professor at Stanford University and the Director of the Huntington’s disease and Ataxia Clinic .The majority of her clinical and research time is devoted to caring for patients with behavioral neurodegenerative disorders, finding treatments for them, and training the next generation to do the same.
The Stanford Movement Disorders Center
Stanford Neuroscience Health Center, 213 Quarry Road, MC 5979 Palo Alto, CA 94304
For patients and appointments, please call the Neuroscience clinic at 650-723-6469
“Every year I get excited for the SF Bay Area Chapter Team Hope Walks. It’s an opportunity for HD families to come together as a community to find support and draw strength from each other while supporting HDSA in the battle against Huntington’s Disease.” – Therese Crutcher-Marin, Event Chair & Chapter President.
Huntington’s disease is a fatal genetic disease that affects the nerve cells in the brain and is often described as having ALS, Parkinson’s, and Alzheimer’s disease all at once. Today, there are approximately 41,000 symptomatic Americans and more than 200,000 at risk of inheriting the disease.
She has wide experience with the care of those with neurodegenerative disorders, and has been a leader of our Center of Excellence since its inception. She provides critical expert and practical advice to families dealing with common Huntington’s disease (HD) issues, including coping with behavioral symptoms like irritability or loss of motivation, weight loss, or problems with swallowing.
Cecilia also assists patients and physicians navigate the health care system to obtain needed medications. As with all the disciplines on the multidisciplinary care team, their goal is to help HD families have the highest quality to their lives on their HD journey.
Huntington’s disease (HD) is a rare, fatal, brain disorder that has the symptoms of ALS, Parkinson’s and Alzheimers, simultaneously. There is NO CURE.
Because HD is very rare, HDSA’s business model focuses on its Mission Statement: HDSA is dedicated to improving the lives of everyone affected by Huntington’s disease and their families. HDSA fulfill’s their mission by providing programs and services to HD families across our nation so they may have the highest quality to their lives on their long HD journey.
HDSA’s Vision Statement: A World Free of Huntington’s Disease HDSA also conducts research in the search for a cure or
During this important month for Huntington’s disease, please go to HDSA.org to learn about the disease and consider making a donation to help in the fight against this horrific disease.
Deciding whether to be tested for Huntington’s disease (HD) is a personal decision and a very, very difficult decision that will change your life. John was tested in 2016 and we are forever grateful that he did not inherit the mutated huntingtin gene from his mother.“The HTT mutation that causes Huntington disease involves a DNA segment known as a CAG trinucleotide repeat . This segment is made up of a series of three DNA building blocks (cytosine, adenine, and guanine) that appear multiple times in a row.”
Kate Miner is my hero for many reasons. She’s beautiful, a talented actress, musician and dedicated Huntington’s Disease advocate. Her family discovered a few years back that Huntington’s disease ran in the family. Her mother and two sisters tested gene-positive, while she did not.
Jenne Colar-Dark, Kate’s sister, is also an advocate and is on HDSA Board of Trustees.
I loved Kate in the TV series, Shameless, and I hope to see her again in another TV series.
Thank you Kate, for all you do for the Huntington’s disease community and many thanks to all who supported the Freeze HD event.
We Can Never Lose HOPE…
To help in the fight against Huntington’s disease, please make a donation to Huntington’s Disease Society of America. Every dollar helps provide services and programs that help HD families have a highest quality to their lives on their HD journey. Thank you.